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So really, everyone is just doing their best guess and playing it safe by saying to avoid these ingredients

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164 In a randomized crossover trial in 50 subjects with male infertility, one month of treatment with a supplement containing pine bark extract plus L-arginine (an amino acid precursor to nitric oxide which regulates blood vessel function) increased semen volume, sperm number and concentration, motility, and vitality, and improved sperm morphology compared with placebo

*Correspondence: Wanqing Liu, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, Room 224B, West Lafayette, IN 47907, USA e-mail: [email protected] This article was submitted to Pharmacogenetics and Pharmacogenomics, a section of the journal Frontiers in Genetics

These are summarised below (Table 2)