In animal studies, butyrate treatment has shown remarkable results, reducing protein aggregation in neurodegenerative disease models, improving mitochondrial function in neurons, extending lifespan in ALS models, and now we understand exactly why: SCFAs are reprogramming the brain's immune cells toward healing rather than destruction
doi: 10.1016/j.ynpai.2022.100102 50
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Graham Noctor, et al The glutathione system and its regulation by neurohormone melatonin in the central nervous system Cent Nerv Syst Agents Med Chem 2010 Dec 1
Finally, the sample size was very small