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Localization and functional coupling of HGF and c-Met/HGF receptor in rat brain: implication as neurotrophic factor

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In certain embodiments, the pharmacokinetics of the otic formulations or compositions described herein are determined by injecting the formulation on or near the round window membrane of a test animal (including by way of example, a guinea pig, a chinchilla, or a rat)

S5a, b), indeed suggesting an important role in necroinflammation