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High-dose acetylcysteine for high-risk (massive) acetaminophen overdose The rationale for using high-dose acetylcysteine: (1) Evidence shows that standard doses of acetylcysteine can be inadequate in the context of massive poisoning
For example, a study published in the European Journal of Nutrition found that oral supplementation with S-acetyl L-glutathione was effective in increasing body stores of glutathione, with significant increases observed in lymphocytes and buccal cells
Science (2004) 304(5674):115860
Johns wort, may impact how an individual responds to acetaminophen
In rare cases, injecting into a blood vessel can cause serious complications
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