Thus, the synergistic effect of PRMT1 and PRMT5 on SCLC recurrence after chemotherapy may be the result of their joint regulation at both the histone and non-histone levels
Diagnostic and treatment methods warrant further optimization
Moreover, Table 3 highlights the utility of diverse modelsfrom BPA-exposed zebrafish and CHO cells, which show mitochondrial ROS and apoptosis reversible by luteolin and 1,25-Dihydroxyvitamin D3 [111,113], to DHT-induced GC injury models where ROS-mediated mitochondrial fission and apoptosis are counteracted by compounds like carnosol, berberine, and growth hormone [45,110,112]
The apoptotic index was calculated as the sum of the FITC-Annexin V-positive/PI-negative (early apoptosis) and FITC-Annexin V-positive/PI-positive (late apoptosis) cell populations
Blood 127 , 139148 (2016)