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In mosteukaryotic cells, GR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis

Determination of mitochondrial membrane potential (MMP) JC-1 dye was used to measure the reduction in MMP levels after exposure to MPP +

221 It also inhibits NLRP3 inflammasome activation, lowering IL-1 and caspase-1 expression and limiting hepatocyte pyroptosis

Our mechanistic investigations revealed that intracellular GSSG elevation sensitizes hepatocytes to TNF killing by inducing IKK--SSG formation, leading to suppressed NF-B activation

Jiao X et al (2021) Perfluorononanoic acid impedes mouse oocyte maturation by inducing mitochondrial dysfunction and oxidative stress