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Weeks 1 to 4 (initial dose: 0.25-0.3 mg) At the starting dose, most researchers experience mild or no side effects

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The detrimental effect of CSPGs upregulation by astrocytes is also observed in MS lesion where the CSPGs aggrecan, neurocan, and versican as well as hyaluronan accumulate at the borders of active demyelinating lesions ( In vivo and in vitro observations have shown that CSPGs limit the ability of OPCs to migrate, mature and myelinate axons (Kuhlmann et al., 2008