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For example, exposure to PAHs and heavy metals has been linked to higher ROS levels, lower sperm motility, and increased DNA fragmentation in sperm

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Dimethyl fumarate (DMF), as an activator of NF-E2-related factor 2 (NRF2), leads to the upregulation of IB and suppression of NF-B signaling pathway activation, thereby promoting the expression of key ferroptosis factors heme oxygenase 1 (HMOX1), NADPH quinone oxidoreductase 1 (NQO1), and GPX4

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J Hematol Oncol 13:111 Li C, Song H, Chen C, Chen S, Zhang Q, Liu D, Li J, Dong H, Wu Y, Liu Y (2021) LncRNA PVT1 knockdown ameliorates myocardial ischemia reperfusion damage via suppressing gasdermin D-mediated pyroptosis in cardiomyocytes