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People who regularly take metformin, proton pump inhibitors, and H2 blockers, or have gastrointestinal disease are also at increased risk

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Unlike other vitamins, the absorption of vitamin B12 depends on a protein produced in the stomach called intrinsic factor

clinical use typically runs 1226 weeks and is supported up to 52 weeks under medical supervision [3]

doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois