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[6] As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1GLV, PDB: 1GSA, PDB: 1GSH, PDB: 1M0T, PDB: 1M0W, PDB: 2GLT, and PDB: 2HGS

Classical reports by Oberley and Davies showed that mild extrinsic oxidative stimuli, such as superoxide and hydrogen peroxide, could activate signalling pathways leading to proliferation [1], [5]

Other psychological factors including abuse (physical, sexual, verbal, and adverse life events), posttraumatic stress disorders and somatization are also likely involved in gutbrain interaction and IBS pathogenesis (Qin et al., 2014)