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In the postnatal murine eye, tip cells at the distal end of endothelial sprouts, which express high levels of endothelial cell-specific molecule 1 (Esm1/endocan), are important for the angiogenic expansion of the developing retinal vasculature

Application: subcutaneous injection in the abdominal area, rotating sites and disinfecting beforehand

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Polydeoxyribonucleotide is a registered drug activating this receptor, and an in vitro study in a FECD model with human corneal endothelial cells revealed reduced H 2 O 2 -induced damage after incubation with this agent [173]