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Without human trials, the safety profile, effective dose, and clinical benefit in humans are all unknown

A common feature is immune dysregulation, where, in Graves disease, autoantibodies stimulating the thyroid to produce an excessive amount of hormone and, in Hashimotos thyroiditis, the thyroid gland suffers autoimmune destruction (Bari et al

As an example, cAMP/PKA pathway, which is stimulated in response to luteinizing hormone (LH), increases SF-1 transcriptional activity, which, in turn, increases expression of steroidogenic genes ( Figure 3 ) ( Figure 3 2 presence and activation of PKC

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