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The percentage of participants with an imAE was calculated using the number of participants who experienced 1 imAE at each time interval, divided by the number of participants in the safety analysis set

In addition, purinoreceptor subtype 7 activation has been observed to cause caspase-1 activation, which is ultimately involved in the expression of cyclooxygenase 2 and prostaglandin E2 and IL- production

Avoid leaving the cream in a hot car or in direct sun while traveling

While there is research that supports its okay to keep water-based ascorbic acid (pure vitamin C) in the refrigerator to help prolong stability and delay in colour change, its important to note that this only applies to ascorbic acid in water

Free Radic Biol Med 34(4):496502