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A 1987 study on mice determined oral glutathione to be nontoxic,27 and a 2017 toxicity study (also on mice) found that glutathione's LD (the amount of a substance needed to kill 50% of all test animals in one dose) was 5g/kg.6 An equivalent toxic dose for an 80kg human would be 32.5g, which is more than 32 times the highest amounts used in clinical studies

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High concentrations of Met are needed to activate T cells and maintain their activation status (85), which indicates that hypermethioninemia promotes T-cell activation

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High doses (1,000+ mg/day) are often needed for minimal effects