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However, increased risks of hematologic abnormalities, gastrointestinal toxicity, and immune-related adverse events necessitate vigilant monitoring and refined, biomarker-guided patient selection, prioritizing those with BRCA1/2 mutations for the most robust clinical benefit (Hunia et al., 2022)

M., Proneth, B., and Conrad, M

Phase II - Glutathione Conjugation Glutathione Conjugation (Figure 18) - Glutathione conjugation involves the attachment of the small tripeptide, glutathione (-glutamylcysteinyl--glycine) (Figure 19), to herbicides containing halogen, phenolate or alkyl sulfoxide groups (Figure 20)

Remarkably, multiple transcription factors in hepatocytes can promote or alleviate MASH by regulating the levels of key enzymes of palmitoylation

Haq S, Grondin J, Banskota S, et al