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The papillary dermis is where fibroblasts respond to mechanical injury by triggering the wound-healing cascade and to GHK-Cu, PDRN, and growth factors by initiating collagen synthesis [2]

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More recent work linked long-term NS work ( 10 years) to significant hypomethylation in 85 CpG sites, including loci in ZFHX3, a gene involved in circadian rhythm regulation and tumor suppression, and ATXN7, associated with transcriptional control and cancer susceptibility 231

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