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Increases in choline levels in rat brain elicited by meclofenoxate

The presence of chronic hyperglycemia, insulin resistance, oxidative stress, and pro-inflammatory mechanisms contribute to endothelial dysfunction in patients with diabetes mellitus (61)

In fact, while glycolysis maintains reduced ROS levels in gemcitabine-resistant pancreatic PaTU8988 cells[32], primary human pancreatic CD133 + CSCs have low mitochondrial ROS concomitant with full oxidative metabolic (OXPHOS) activity[7]