The HPLC gradient grade acetonitrile (ACN), used for chromatographic analysis, hydrochloric acid utilized for the standard solution preparation, sodium hydrogen phosphate heptahydrate (Na 2 HPO 4 7H 2 O), sodium dihydrogen phosphate dihydrate (NaH 2 PO 4 2H 2 O) and sodium hydroxide were purchased from J.T
Detailed descriptions of randomization and blinding procedures are often missing, raising concerns about potential selection and observer biases
Contraindications include active skin infections at treatment sites, known copper metabolism disorders, pregnancy and breastfeeding (for injectable applications), and severe allergic reactions to copper compounds
Until official regulatory approval is granted, there is no approved maximum dose for clinical use
Creatine Supplementation in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial. Arthritis Care & Research, vol