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At the same time, the activity of antioxidant enzymes (SOD, GPX, GR) in cardiomyocytes is weaker than that in other organs [17], further aggravating the susceptibility to this injury

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These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs

In vitro and in vivo experiments indicate that GCL is redox-regulated and is more active as the oxidized dimer (Jez et al., 2004

Free Radical Biology & Medicine, 95 , 27-42