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COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure
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185 Besides, other MTHFD2 inhibitors have been reported, including DS18561882 and LY345899 in a substrate-based manner, and treatments based on them decrease cellular NADPH/NADP + ratio, increase cellular ROS levels, and impair tumorigenesis and metastasis