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In the early stages of AD, the number of autophagosomes increases, but these autophagosomes do not fuse normally with lysosomes, and toxic proteins, including amyloid (A), tau protein, and damaged mitochondria, cannot be cleared before they cause damage [181,182,183]
Regular monitoring of liver health is crucial for patients with elevated bilirubin levels or inherited conditions affecting bilirubin conjugation
29 Without an accurate PD biomarker, tracking target engagement, monitoring disease progression, and optimizing patient stratification is nearly impossible
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