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J Biol Chem 267:96102 Weinshilboum RM, Otterness DM, Szumlanski CL (1999) Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase

NMDARs are highly expressed in areas of the brain involved in regulating emotion, such as the hippocampus, where they play a pivotal role in synaptic plasticity and normal working memory, making their activity both necessary and potentially harmful

1 Like most complex genomic regulatory systems, Nrf2 (nuclear factor erythroid 2-related factor 2) is sequestered in the cytoplasm until it is able to translocate into the nucleus, where it forms a heterodimer with MAF (another transcription factor) and binds to the promoter region of genes containing an antioxidant response element (ARE) sequence

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