This approach is particularly valuable in long-term protocols exceeding 8-12 weeks where continuous single-compound administration might produce diminishing returns through tolerance development
Matek D, Sikiric P, et al
(4) Blood Pressure (3) In blood pressure studies, compared with l-arginine, pentadecapeptide BPC 157 (without effect on basal normal values) had both a mimicking effect (impaired l-NAME-blood pressure increase, when applied prophylactically and decreased already raised l-NAME values, given at the time of the maximal l-NAME-blood pressure increase (i.e., 10 min after l-NAME)) and preventive activity (l-arginine-induced moderate blood pressure decrease was prevented by BPC 157 pretreatment)
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