High-dose oral supplements (often 10002000 micrograms daily) or intramuscular injections (typically 1mg hydroxocobalamin) used to treat pernicious anaemia or deficiency states can temporarily elevate serum levels
If you skip the 2mg phase entirely and start at 4mg (which some protocols allow), the gastrointestinal side effects are notably more severe, trading impatience now for discomfort later
What are some benefits of a vitamin B12 injection
Frequency of Injections The frequency of B12 injections plays a significant role in determining how long B12 stays in the body
In physical dependence assay (isoniazid challenge assessed at 6, 14, 42 and 72 h after conditioning medication), when compared to diazepam non-conditioned healthy mice, in diazepam conditioned mice residual anticonvulsive activity was not present already at the earliest post-conditioning interval (i.e., not different latency to isoniazid-convulsions), whereas shorter preconvulsive latencies (as physical dependence/withdrawal hallmark) were noted in diazepam conditioned mice following isoniazid challenge at 42 h and at 72 h after end of conditioning treatment
