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This is one of the most important facts in the entire comparison, because it means every ranking of the two is cross-trial inference, not a controlled result

Safety and Pharmacology Evaluations : Conducting preclinical toxicology, pharmacokinetic, and receptor-binding studies to characterize how AOD 9604 is handled in vivo and confirm it does not activate growth hormone-like proliferative pathways

Neurosurgery with deep brain stimulation is an option for unmanageable dystonia or tremor [230, 231], rhizotomy for severe spasticity with associated deformities [232], and percutaneous gastrostomy to ensure adequate nutrition when dysphagia is severe [233]

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