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To further distinguish heterogeneous conformations observed in the datasets of CTR:Cagri/CagriBB, the authentic particles of complexes were separated into multiple clusters by 3D Classification in cryoSPARC with approximately 50100k particles for each cluster

The combination of LNS8801 and pembrolizumab (a programmed death-ligand 1 (PD-L1) inhibitor) has entered phase 1/2 clinical trials (NCT04130516), which represents the first clinical study of a treatment targeting GPER for several advanced solid tumors

References Graf MV et al

481 A CXCR4 partial agonist TFF2-MSA sensitized advanced gastric cancer to PD-1 blockade by systematically reducing PMN-MDSC accumulation, immunosuppression, and generation in bone marrow