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Downregulating TRPML1 or blocking the interaction between TRPML1 and ARL8B can inhibit AKT-driven tumorigenesis by promoting ferroptosis, and enhancing the sensitivity of radiotherapy and immunotherapy

Temporal appearance of enhanced innate anxiety in Alzheimer model mice

Zhao, Y

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In summary, GSHee and L-CYSee 21 may represent the first examples of a novel class of thiolester compounds that are able to effectively prevent the ventilatory depressant effects of powerful opioids such as fentanyl (and perhaps other high potency opioids such as sufentanil and alfentanil) and their deleterious effects on breathing stability and gas-exchange within the lungs without compromising the analgesic actions of the opioids