doi:10.1016/j.fct.2013.08.049 Karpusas M, Axarli I, Chiniadis L, Papakyriakou A, Bethanis K, Scopelitou K, Clonis YD, Labrou NE (2013) The interaction of the chemotherapeutic drug chlorambucil with human glutathione transferase A1-1: kinetic and structural analysis
Cch dng: Ung 1 vin/ngy i vi nhng ngi trng thnh
(thiol group) (glutathione disulfide
In a study on HCC, we were pleasantly surprised to find that the HGF/c-MET pathway and FGF19/FGFR4 collaboratively enhance ETV4 expression in HCC cells via the ERK1/2 axis, where ETV4, an ETS transcription factor upregulated in all HCC stages, increases PD-L1 and CCL2 expression, resulting in MDSCs and TAMs infiltration, CD8 T cells suppression and HCC metastasis [79, 80]
Additional information Peer review information Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work