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Equol is a metabolite of soybean flavonoids, and recent studies have demonstrated that it regulates the ratio of BCL2/BAX expression, inhibits early apoptosis, and improves mitochondrial function [110]

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Furthermore, recent evidence has indicated that some of the inflammation produced by intrarectal administration of TNBS may be mediated by a burst of ROS produced from its metabolism within the mucosal interstitium (Grisham et al, 1991)

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