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Due to the relatively low survival rate and severe side effects associated with DSMTs treatment, new treatment strategies are urgently required

Cortical lesions are evident even in the earliest stages of MS, but increase in number as the disease progresses ( As MS progresses, there is an increase in the proportion of chronically-demyelinated lesions at the expense of myelinated lesions ( The inflammation and demyelination that occurs in both WM and cortical lesions leads to axon injury and loss, which is considered to be the major factor leading to disability and cognitive deficits in MS ( Atrophy of the whole brain and GM, which contains the cell bodies of neurons, also occurs in MS and the extent of GM atrophy is a predictor of cognitive and disability progression in this disease ( Optical coherence tomography is a technique that has been used to measure the thickness of the retinal nerve fiber layer

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These findings highlight the evolving nature of the overdose crisis and suggest the need for region-specific strategies to address differing patterns of substance use and overdose risk