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These challenges highlight the need for complementary or alternative therapeutic approaches that can safely target additional pathological processes (e.g., inflammation, fibrosis) beyond the reach of current standard-of-care medications

Witch Hazel is an astringent, anti-inflammatory, antioxidant, and antibacterial ingredient

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Hepatotoxic drugs can cause injury to the hepatocytes directly in a predictable dose-dependent way or through idiosyncratic reactions

For hematoxylin/eosin Y staining (HE), sections were rehydrated and stained with Mayers hematoxylin and counterstained with Eosin Y solution (#318906, Sigma Aldrich, St