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In addition, it was reported in DRG neurons of wild type mice and TRPA1 knockout mice that activation of TRPV1 by chemotherapeutic agents induced excessive ROS production and mechanical allodynia

Use ketoconazole tablets with caution in patients with cardiac disease or other conditions that may increase the risk of QT prolongation including cardiac arrhythmias, congenital long QT syndrome, heart failure, bradycardia, myocardial infarction, hypertension, coronary artery disease, hypomagnesemia, hypokalemia, hypocalcemia, or in patients receiving medications known to prolong the QT interval or cause electrolyte imbalances

USA 112 , E6195E6204 (2015)

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