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In astrocytes, LPS also increases NFB-mediated transcription of pro-inflammatory cytokines, including TNF, IL-1, iNOS and cyclooxygenase-2 (COX2) (Bobermin et al., 2020)

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Peptides are signaling molecules that work with your body's existing hormone systems, they stimulate your pituitary to release more growth hormone (rather than replacing it), or signal tissue repair through receptor activation

Studies were downgraded for indirectness if they lacked generalizability of the population (i.e., too restrictive population selected either in control or patient groups), if the cohort was not comprehensively described, if DNA methylation was not measured directly or was assessed for validation of expression changes

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