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4 encode cytosolic GST and one encodes the microsomal form of GST

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Parallel evaluation of process scalability, stability under realistic storage conditions and the measurability of critical quality attributes can prevent situations in which conceptually attractive constructs prove impossible to manufacture at commercial scale

The key novelty of our study is that higher PC levels are associated with reduced fibrin clot permeability in both hyper- and hypothyroid group, while plasma clot lysability, unrelated to PAI-1 or TAFI concentrations or activity, showed association with PC solely in the former group, suggesting the structural alterations to fibrin provoked by hyperthyroidism affect susceptibility to lytic degradation to a larger extent