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Additionally, activated GPER can upregulate glucose transporters (GLUTs) and hexokinase (HK), increasing the level of aerobic glycolysis and leading to the accumulation of metabolic waste products, including lactic acid, which helps tumor cells evade immune surveillance and enhances their invasive capabilities [6, 34]

Similar to what is observed in monocytes and macrophages, G6PD-d may limit the production of NADPH-dependent ROS that act as second messengers to enhance NFAT, AP-1, and NFB signaling 89,116,117

NATs are involved in the metabolism of a variety of different compounds to which we are exposed on a daily basis

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Trypsin-Mediated Sensitization to Ferroptosis Increases the Severity of Pancreatitis in Mice