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doi:10.1089/acm.2014.0327
have showed that loss of the transcription factor IRF4 in mouse brown adipose tissue (BATI4KO) reduced mitochondrial function and athletic ability in muscle ( 5 The inhibitor of MSTN In view of the importance of MSTN in regulating muscle homeostasis, the inhibitors targeting the MSTN signaling pathway have been developed for clinical use to improve patients with sarcopenia and muscular dystrophy
Recent findings suggest that SIRT2 can deacylate multiple small GTPases inside cells to protect against Shigella infection, and Rheb GTPase is one of the substrates for SIRT2 deacylation during Shigella infection, where effector molecules from Shigella reportedly fatty acylate lysine residues of Rheb and other small GTPases (Wang et al, 2022)
Karin, "ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development", Cancer cell , 2014 , 26 (3), 331
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