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Regulation of -glutamylcysteine synthetase by nonallosteric feedback inhibition by glutathione

The SLC2 (GLUT) family of membrane transporters

For example, excessive ammonia in the TME can be transformed into L-arginine to promote CD4/CD8 T-cell infiltration and activation, thereby coupling local metabolic reprogramming with site-specific immune enhancement [368]

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J Biol Chem 255 : 23722376 Bannai S, Kitamura E (1981) Role of proton dissociation in the transport of cystine and glutamate in human diploid fibroblasts in culture