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The associations observed using 20-year cross-correlation lags support the importance of long-term cumulative exposure

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Together, these data reaffirm the important status of BCEVs as potential mediators of field cancerization that may contribute to BC recurrence or progression, while also highlighting the fact that menthol-flavored E-liquid use may be associated with even higher levels of clinical risk in susceptible individuals who use this product, although further preclinical and clinical validation will be essential to test this possibility

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