Matama T, Araujo R, Preto A, Cavaco-Paulo A, Gomes AC
In addition to directly participating in the synthesis of selenoproteins, Se may increase the resistance of cells to ferroptosis in indirect ways
it demonstrated preclinical efficacy (80), progressed to first in human testing, and showed activity in Ras driven models, including combinational benefit with platinum therapy (81, 82)
Evidence-based strategies include daily sunscreen, topical antioxidants like vitamin C or retinoids, a healthy diet rich in antioxidants, avoiding smoking, and professional dermatologic treatments
In all studies, they've been looking at safety parameters like heart rate, blood pressure, anxiety, etc