4a,b) support a mechanism in which mitochondrial complex I inhibition promotes antioxidant gene expression and NADPH production, leading to TXNIP suppression and subsequent GLUT1 upregulation
At pH 9, CVA21 was eluted at 300 mM NaCl, while at pH 7, CVA21 was partially eluted at 1,000 mM NaCl and in the subsequent 1 mM GSH elution buffer
Turk J Haematol
The treatment was well tolerated with no adverse events and no changes in vital signs, electrocardiograms, or laboratory markers assessing cardiac, liver, kidney, thyroid, or metabolic function
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