In one study, participants lost about 1.3 kilograms more than placebo in 16 days, and the drug reduced daily caloric intake by roughly 400 calories per day, suggesting appetite suppression via melanocortin-4 receptor (MC4R) activation
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Diabetic retinopathy complications have been observed in some patients with pre-existing retinopathy who experience rapid improvements in glycemic control with semaglutide therapy
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