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Tobacco product use among young people remains a serious public health concern: more than 2 million middle and high school students used e-cigarettes in 2023 the most popular tobacco product among youth today according to the National Youth Tobacco Survey

Furthermore, with reference to its fellow anti-4 integrin molecule natalizumab, smoking was associated with a higher likelihood of anti-natalizumab antibody development in multiple sclerosis patients and smoking was associated with higher risk of relapse in multiple sclerosis patients on natalizumab [25,26]

Yet, by 2023, the WHO global tobacco report said around 5.6 billion people - 71% of the world's population - were covered by at least one smoke-free policy

Plos one , 15 (9), e0239033

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