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A May 2016 report on the Pharmacy Times website noted that tobacco smoke affects liver enzymes that are essential to the absorption, distribution, metabolism, and elimination of many medications, including antidepressants

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Today, while their use is less common due to changing attitudes toward smoking, they remain a stylish conversation piece and practical tool for some smokers

56 While there is some evidence that vapes, when used under strict clinical protocols for cessation, may have some success at helping people quit, the reality is when people use vapes as a consumer product only four out of 100 people who use cigarettes actually stopped smoking

[2] It is made by Philip Morris USA (a branch of Altria) within the US, and by Philip Morris International (now separate from Altria) outside the US