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Effectiveness of Compounded Bioidentical Hormone Replacement Therapy: An Observational Cohort Study

This matters clinically because blood vessel growth is a rate-limiting step in healing

Huang et al., 2012

Variants are pathway-level: they don't predict response to any specific compound, but they describe the metabolic and longevity terrain a clinician is prescribing into

Homocysteine levels, which were elevated at baseline, and protein carbonyl groups (a marker of oxidative stress) decreased in a dose-dependent way, with a 37% reduction of homocysteine and a 23% reduction of protein carbonyl groups with 800 mg per day