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Metals, autoimmunity, and neuroendocrinology: Is there a connection

For example, proinflammatory cytokines such as IL-1 have been shown to impair neurotransmitter homeostasis (e.g., decreased serotonin levels and enhanced glutamatergic excitotoxicity), induce oxidative stress (OS) and neuronal pyroptosis, and lead to mitochondrial dysfunction and synaptic protein lossultimately fostering a bidirectional relationship between epilepsy and depression (Zhu et al., 2006

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Among molecules that are controlled by GCs and may be involved in the control of insulin signaling, myostatin has drawn a particular interest

, Tabor, K