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The first four dealt with administrative matters

Despite initial responses to treatment, relapse is common due to the high rate of chemotherapy resistance, making SCLC one of the most difficult cancers to treat

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Before the existence of express political compacts it was reasonably implied that the magistrate should govern with wisdom and justice, but mere implication was too feeble to restrain the unbridled ambition of a bad man, or afford security against negligence, cruelty, or any other defect of mind