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Natively disordered proteins, in Handbook of Protein Folding

10.3390/jcm11112985 [DOI] [PMC free article] [PubMed] [Google Scholar] HernandezEstrada, Z

For example, cytotoxic T lymphocytes that help the tumor survive are suppressed by M2 macrophages

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PD-1 can upregulate the expression of PD-L1 in tumor cells and ultimately inhibit the proliferation of T cells and reduce immune function by binding to its ligand PD-L1, thereby facilitating tumor cell immune escape [61,62,63,64], this is the mechanism by which tumor cells evade immune cells with the help of PD-1 in the absence of glutamine