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In addition, rather than leading to an increase in rT3 levels directly caused by an imbalance in DIO3, the available data imply that Se deficit may indirectly cause these levels to rise via reduced clearance of DIO1 and changes in peripheral thyroid hormone metabolism [33]

In this study they exposed the animals to an increased inspiratory load which was set up to induce fatigue of the respiratory muscle and ultimately end with respiratory arrest

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