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Cortisol dysregulation driven by gut-derived immune signalling disrupts the normal circadian cortisol rhythm, impairing the deep sleep stages required for cellular repair

One potential reason could be increased expression of pyruvate dehydrogenase kinase (PDK) observed in AML patients, which inhibits glycolysis by phosphorylating and inactivating the enzyme pyruvate dehydrogenase (29, 30)

Then there's the lifestyle stack that's easy to underestimate: chronic stress (cortisol and oxidative stress feed each other), broken sleep , and diets low in protein variety and fresh produce

Epithalon is a synthetic four-amino-acid peptide (Ala-Glu-Asp-Gly) used in research to study telomerase activation, cell-cycle regulation, and cellular aging pathways