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However, there is increasing evidence that MSCs administered intravenously are easily trapped in several tissues (lung, liver or spleen) due to their larger size and adhesive nature (expression integrin CD49f or CD49d) as a result about 2% of cells delivered reac the target lesion site [16,54]

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FDAs Q2(R2) guidance identifies analytical validation concepts such as specificity, accuracy, precision, and range, which belong to method and data review rather than calculator interpretation [2]